B1 Non-refereed article in a scientific journal
Phosphodiester cleavage of diribonucleoside 3 ',3 '-monophosphates: Rate acceleration by the 2 '-hydroxyl and 2 '-amino function, implications to ribozyme action
Authors: Ora M, Kiviniemi A, Lonnberg T, Virtanen S, Lonnberg H
Publication year: 2005
Journal:: Collection Symposium Series
Journal name in source: Chemistry of Nucleic Acid Components
Journal acronym: COLL SYMPOS SERIES
Volume: 7
First page : 261
Last page: 263
Number of pages: 3
ISBN: 80-86241-25-4
Abstract
The hydrolytic reactions of diribonucleoside 3',3'-monophosphates have been followed by RP HPLC over a wide pH-range at 363.2 K. The mechanisms of the reactions are discussed, particularly focusing on the possible stabilization of phosphorane intermediate and/or transition state via an intramolecular hydrogen bonding by the 2'-hydroxyl and 2'-amino group.
The hydrolytic reactions of diribonucleoside 3',3'-monophosphates have been followed by RP HPLC over a wide pH-range at 363.2 K. The mechanisms of the reactions are discussed, particularly focusing on the possible stabilization of phosphorane intermediate and/or transition state via an intramolecular hydrogen bonding by the 2'-hydroxyl and 2'-amino group.
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