Association of Catechol-O-methyltransferase polymorphism Val158Met and mammographic density: A meta-analysis




Kallionpää RA, Uusitalo E, Peltonen J

PublisherELSEVIER SCIENCE BV

2017

Gene

GENE

GENE

624

34

42

9

0378-1119

1879-0038

DOIhttps://doi.org/10.1016/j.gene.2017.04.049



Objectives: The Va1158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Va1158Met polymorphism on mammographic density.Methods: Original studies reporting data on mammographic density, stratified by the presence of COMT Vail 58Met polymorphism, were identified and combined using genetic models Met/Val vs. Val/Val, Met/Met vs. Val/Val, Val/Met + Met/Met vs. Val/Val (dominant model) and Met/Met vs. Val/Met + Val/Val (recessive model). Subgroup analyses by breast cancer status, menopausal status and use of hormone replacement therapy (HRT) were also performed.Results: Eight studies were included in the meta-analysis. The overall effect in percent mammographic density was -1.41 (CI -2.86 to 0.05; P = 0.06) in the recessive model. Exclusion of breast cancer patients increased the effect size to -1.93 (CI -3.49 to -0.37; P = 0.02). The results suggested opposite effect of COMT Val158Met for postmenopausal users of HRT versus premenopausal women or postmenopausal non-users of HRT.Conclusions: COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects.



Last updated on 2024-26-11 at 22:54