A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Association of Catechol-O-methyltransferase polymorphism Val158Met and mammographic density: A meta-analysis
Tekijät: Kallionpää RA, Uusitalo E, Peltonen J
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2017
Journal: Gene
Tietokannassa oleva lehden nimi: GENE
Lehden akronyymi: GENE
Vuosikerta: 624
Aloitussivu: 34
Lopetussivu: 42
Sivujen määrä: 9
ISSN: 0378-1119
eISSN: 1879-0038
DOI: https://doi.org/10.1016/j.gene.2017.04.049
Tiivistelmä
Objectives: The Va1158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Va1158Met polymorphism on mammographic density.Methods: Original studies reporting data on mammographic density, stratified by the presence of COMT Vail 58Met polymorphism, were identified and combined using genetic models Met/Val vs. Val/Val, Met/Met vs. Val/Val, Val/Met + Met/Met vs. Val/Val (dominant model) and Met/Met vs. Val/Met + Val/Val (recessive model). Subgroup analyses by breast cancer status, menopausal status and use of hormone replacement therapy (HRT) were also performed.Results: Eight studies were included in the meta-analysis. The overall effect in percent mammographic density was -1.41 (CI -2.86 to 0.05; P = 0.06) in the recessive model. Exclusion of breast cancer patients increased the effect size to -1.93 (CI -3.49 to -0.37; P = 0.02). The results suggested opposite effect of COMT Val158Met for postmenopausal users of HRT versus premenopausal women or postmenopausal non-users of HRT.Conclusions: COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects.
Objectives: The Va1158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Va1158Met polymorphism on mammographic density.Methods: Original studies reporting data on mammographic density, stratified by the presence of COMT Vail 58Met polymorphism, were identified and combined using genetic models Met/Val vs. Val/Val, Met/Met vs. Val/Val, Val/Met + Met/Met vs. Val/Val (dominant model) and Met/Met vs. Val/Met + Val/Val (recessive model). Subgroup analyses by breast cancer status, menopausal status and use of hormone replacement therapy (HRT) were also performed.Results: Eight studies were included in the meta-analysis. The overall effect in percent mammographic density was -1.41 (CI -2.86 to 0.05; P = 0.06) in the recessive model. Exclusion of breast cancer patients increased the effect size to -1.93 (CI -3.49 to -0.37; P = 0.02). The results suggested opposite effect of COMT Val158Met for postmenopausal users of HRT versus premenopausal women or postmenopausal non-users of HRT.Conclusions: COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects.
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