Regio-selective synthesis of polyazacyclophanes incorporating a pendant group as potential cleaving agents of mRNA 5 '-cap structure - UTU Tutkimustietojärjestelmä

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Regio-selective synthesis of polyazacyclophanes incorporating a pendant group as potential cleaving agents of mRNA 5 '-cap structure

Tekijät: Zhang Z, Mikkola S, Lonnberg H

Kustantaja: PERGAMON-ELSEVIER SCIENCE LTD

Julkaisuvuosi: 2007

Journal: Tetrahedron

Tietokannassa oleva lehden nimi: TETRAHEDRON

Lehden akronyymi: TETRAHEDRON

Vuosikerta: 63

Numero: 47

Aloitussivu: 11716

Lopetussivu: 11723

Sivujen määrä: 8

ISSN: 0040-4020

DOI: https://doi.org/10.1016/j.tet.2007.08.102

Tiivistelmä

A terpyridine or an imidazole unit has been tethered to an N-protected polyazacyclophane to give the appropriate N-monofunctionalized polyazacyclophane. After mild deprotection, four polyazacyclophanes incorporating a pendant group were obtained in satisfactory yields. Their preliminary cleavage ability of mRNA 5'-cap model was studied at pH 7.2. Published by Elsevier Ltd.