Regio-selective synthesis of polyazacyclophanes incorporating a pendant group as potential cleaving agents of mRNA 5 '-cap structure - UTU Research Portal

A1 Refereed original research article in a scientific journal

Regio-selective synthesis of polyazacyclophanes incorporating a pendant group as potential cleaving agents of mRNA 5 '-cap structure

Authors: Zhang Z, Mikkola S, Lonnberg H

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Publication year: 2007

Journal: Tetrahedron

Journal name in source: TETRAHEDRON

Journal acronym: TETRAHEDRON

Volume: 63

Issue: 47

First page : 11716

Last page: 11723

Number of pages: 8

ISSN: 0040-4020

DOI: https://doi.org/10.1016/j.tet.2007.08.102

Abstract

A terpyridine or an imidazole unit has been tethered to an N-protected polyazacyclophane to give the appropriate N-monofunctionalized polyazacyclophane. After mild deprotection, four polyazacyclophanes incorporating a pendant group were obtained in satisfactory yields. Their preliminary cleavage ability of mRNA 5'-cap model was studied at pH 7.2. Published by Elsevier Ltd.