A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Artificial ribonucleases
Tekijät: Niittymaki T, Lonnberg H
Kustantaja: ROYAL SOC CHEMISTRY
Julkaisuvuosi: 2006
Tietokannassa oleva lehden nimi: ORGANIC & BIOMOLECULAR CHEMISTRY
Lehden akronyymi: ORG BIOMOL CHEM
Vuosikerta: 4
Numero: 1
Aloitussivu: 15
Lopetussivu: 25
Sivujen määrä: 11
ISSN: 1477-0520
DOI: https://doi.org/10.1039/b509022a
Tiivistelmä
Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists.(1) During the past decade, mimics for RNA- cleaving enzymes, ribonucleases,(2) or, more precisely, mimics of ribozymes(3) that cleave RNA in sequence-selective rather than base- selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides ( or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.
Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists.(1) During the past decade, mimics for RNA- cleaving enzymes, ribonucleases,(2) or, more precisely, mimics of ribozymes(3) that cleave RNA in sequence-selective rather than base- selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides ( or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.
Turun yliopiston Tutkimustietojärjestelmän portaali