A2 Refereed review article in a scientific journal
Artificial ribonucleases
Authors: Niittymaki T, Lonnberg H
Publisher: ROYAL SOC CHEMISTRY
Publication year: 2006
Journal name in source: ORGANIC & BIOMOLECULAR CHEMISTRY
Journal acronym: ORG BIOMOL CHEM
Volume: 4
Issue: 1
First page : 15
Last page: 25
Number of pages: 11
ISSN: 1477-0520
DOI: https://doi.org/10.1039/b509022a
Abstract
Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists.(1) During the past decade, mimics for RNA- cleaving enzymes, ribonucleases,(2) or, more precisely, mimics of ribozymes(3) that cleave RNA in sequence-selective rather than base- selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides ( or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.
Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists.(1) During the past decade, mimics for RNA- cleaving enzymes, ribonucleases,(2) or, more precisely, mimics of ribozymes(3) that cleave RNA in sequence-selective rather than base- selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides ( or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds.
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