A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children
Tekijät: Jartti T, Lehtinen P, Vuorinen T, Osterback R, van den Hoogen B, Osterhaus ADME, Ruuskanen O
Kustantaja: CENTER DISEASE CONTROL
Julkaisuvuosi: 2004
Lehti: Emerging Infectious Diseases
Tietokannassa oleva lehden nimi: EMERGING INFECTIOUS DISEASES
Lehden akronyymi: EMERG INFECT DIS
Vuosikerta: 10
Numero: 6
Aloitussivu: 1095
Lopetussivu: 1101
Sivujen määrä: 7
ISSN: 1080-6040
DOI: https://doi.org/10.3201/eid1006.030629
Tiivistelmä
We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enteroviruses (25%), rhinovirus (24%), and nontypable rhino/enterovirus (16%) were found most frequently. In infants, RSV was found in 54% and respiratory picornaviruses (rhinovirus and enteroviruses) in 42% of the cases. In older children, respiratory picornaviruses dominated (65% of children ages 1-2 years and 82% of children ages greater than or equal to3 years). Human metapneumovirus was detected in 4% of all children and in 11% of infants. To prevent and treat acute expiratory wheezing illnesses in children, efforts should be focused on RSV, enterovirus, and rhinovirus infections.
We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enteroviruses (25%), rhinovirus (24%), and nontypable rhino/enterovirus (16%) were found most frequently. In infants, RSV was found in 54% and respiratory picornaviruses (rhinovirus and enteroviruses) in 42% of the cases. In older children, respiratory picornaviruses dominated (65% of children ages 1-2 years and 82% of children ages greater than or equal to3 years). Human metapneumovirus was detected in 4% of all children and in 11% of infants. To prevent and treat acute expiratory wheezing illnesses in children, efforts should be focused on RSV, enterovirus, and rhinovirus infections.
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