A1 Refereed original research article in a scientific journal
Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children
Authors: Jartti T, Lehtinen P, Vuorinen T, Osterback R, van den Hoogen B, Osterhaus ADME, Ruuskanen O
Publisher: CENTER DISEASE CONTROL
Publication year: 2004
Journal:Emerging Infectious Diseases
Journal name in sourceEMERGING INFECTIOUS DISEASES
Journal acronym: EMERG INFECT DIS
Volume: 10
Issue: 6
First page : 1095
Last page: 1101
Number of pages: 7
ISSN: 1080-6040
DOI: https://doi.org/10.3201/eid1006.030629
Abstract
We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enteroviruses (25%), rhinovirus (24%), and nontypable rhino/enterovirus (16%) were found most frequently. In infants, RSV was found in 54% and respiratory picornaviruses (rhinovirus and enteroviruses) in 42% of the cases. In older children, respiratory picornaviruses dominated (65% of children ages 1-2 years and 82% of children ages greater than or equal to3 years). Human metapneumovirus was detected in 4% of all children and in 11% of infants. To prevent and treat acute expiratory wheezing illnesses in children, efforts should be focused on RSV, enterovirus, and rhinovirus infections.
We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enteroviruses (25%), rhinovirus (24%), and nontypable rhino/enterovirus (16%) were found most frequently. In infants, RSV was found in 54% and respiratory picornaviruses (rhinovirus and enteroviruses) in 42% of the cases. In older children, respiratory picornaviruses dominated (65% of children ages 1-2 years and 82% of children ages greater than or equal to3 years). Human metapneumovirus was detected in 4% of all children and in 11% of infants. To prevent and treat acute expiratory wheezing illnesses in children, efforts should be focused on RSV, enterovirus, and rhinovirus infections.
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