A1 Refereed original research article in a scientific journal
A minor role of asparaginase in predisposing to cerebral venous thromboses in adult acute lymphoblastic leukemia patients
Authors: Roininen S, Laine O, Kauppila M, Vesanen M, Rämet M, Sinisalo M, Jantunen E, Säily M, Räty R, Elonen E, Wartiovaara-Kautto U
Publisher: WILEY
Publication year: 2017
Journal: Cancer Medicine
Journal name in source: CANCER MEDICINE
Journal acronym: CANCER MED-US
Volume: 6
Issue: 6
First page : 1275
Last page: 1285
Number of pages: 11
ISSN: 2045-7634
eISSN: 2045-7634
DOI: https://doi.org/10.1002/cam4.1094
Web address : http://onlinelibrary.wiley.com/doi/10.1002/cam4.1094/full
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/23851714
Cerebral venous thrombosis (CVT) covers up to a third of all venous thromboses (VTs) detected in patients with acute lymphoblastic leukemia (ALL). It usually hampers patients' lives and may also endanger efficient leukemia treatment. Although many factors have been suggested to account for an elevated risk of VTs in patients with ALL, there still is a lack of studies focusing on CVTs and especially in the setting of adult ALL patients. We studied in our retrospective population-based cohort the occurrence, characteristics, as well as risk factors for VTs in 186 consecutively diagnosed Finnish adult ALL patients treated with a national pediatric-inspired treatment protocol ALL2000. In the risk factor analyses for VTs we found a distinction of the characteristics of the patients acquiring CVT from those with other kinds of VTs or without thrombosis. In contrast to previous studies we were also able to compare the effects of asparaginase in relation to CVT occurrence. Notably, more than half of the CVTs were diagnosed prior the administration of asparaginase which accentuates the role of other risk factors on the pathophysiology of CVT compared to truncal or central venous line (CVL) VTs in adult ALL patients.
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