Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants



: Reiman M, Kujari H, Ekholm E, Lapinleimu H, Lehtonen L, Haataja L

Publisher: MOSBY-ELSEVIER

: 2008

 Journal of Pediatrics

: JOURNAL OF PEDIATRICS

: J PEDIATR-US

: 153

: 1

: 19

: 24

: 6

: 0022-3476

DOI: https://doi.org/10.1016/j.jpeds.2008.02.009


Conclusions The IL-6-174 GG and -572 GC genotypes were associated with a higher incidence of histologic chorioaminionitis, and the IL-6-174 CC genotype was associated with septicemia in preterm infants. These findings suggest that the genetic composition of the IL-6 promoter area plays a significant role in the pathogenesis of chorioamnionitis and neonatal infections.




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