Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants - UTU Research Portal

A1 Refereed original research article in a scientific journal

Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants

Authors: Reiman M, Kujari H, Ekholm E, Lapinleimu H, Lehtonen L, Haataja L

Publisher: MOSBY-ELSEVIER

Publication year: 2008

Journal:: Journal of Pediatrics

Journal name in source: JOURNAL OF PEDIATRICS

Journal acronym: J PEDIATR-US

Volume: 153

Issue: 1

First page : 19

Last page: 24

Number of pages: 6

ISSN: 0022-3476

DOI: https://doi.org/10.1016/j.jpeds.2008.02.009

Abstract

Conclusions The IL-6-174 GG and -572 GC genotypes were associated with a higher incidence of histologic chorioaminionitis, and the IL-6-174 CC genotype was associated with septicemia in preterm infants. These findings suggest that the genetic composition of the IL-6 promoter area plays a significant role in the pathogenesis of chorioamnionitis and neonatal infections.