Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis The APPAC Randomized Clinical Trial



: Salminen P, Paajanen H, Rautio T, Nordstrom P, Aarnio M, Rantanen T, Tuominen R, Hurme S, Virtanen J, Mecklin JP, Sand J, Jartti A, Rinta-Kiikka I, Gronroos JM

Publisher: AMER MEDICAL ASSOC

: 2015

: JAMA: Journal of the American Medical Association

: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

: JAMA-J AM MED ASSOC

: 313

: 23

: 2340

: 2348

: 9

: 0098-7484

: 1538-3598

DOI: https://doi.org/10.1001/jama.2015.6154


CONCLUSIONS AND RELEVANCE Among patients with CT-proven, uncomplicated appendicitis, antibiotic treatment did not meet the prespecified criterion for noninferiority compared with appendectomy. Most patients randomized to antibiotic treatment for uncomplicated appendicitis did not require appendectomy during the 1-year follow-up period, and those who required appendectomy did not experience significant complications.



Last updated on 2024-26-11 at 15:09