Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis The APPAC Randomized Clinical Trial - UTU Research Portal

A1 Refereed original research article in a scientific journal

Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis The APPAC Randomized Clinical Trial

Authors: Salminen P, Paajanen H, Rautio T, Nordstrom P, Aarnio M, Rantanen T, Tuominen R, Hurme S, Virtanen J, Mecklin JP, Sand J, Jartti A, Rinta-Kiikka I, Gronroos JM

Publisher: AMER MEDICAL ASSOC

Publication year: 2015

Journal: JAMA: Journal of the American Medical Association

Journal name in source: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Journal acronym: JAMA-J AM MED ASSOC

Volume: 313

Issue: 23

First page : 2340

Last page: 2348

Number of pages: 9

ISSN: 0098-7484

eISSN: 1538-3598

DOI: https://doi.org/10.1001/jama.2015.6154

Abstract

CONCLUSIONS AND RELEVANCE Among patients with CT-proven, uncomplicated appendicitis, antibiotic treatment did not meet the prespecified criterion for noninferiority compared with appendectomy. Most patients randomized to antibiotic treatment for uncomplicated appendicitis did not require appendectomy during the 1-year follow-up period, and those who required appendectomy did not experience significant complications.