Fatty acids as determinants of in-vivo lipid peroxidation: The EFFGE study in Eastern Finnish hypertensive and non-hypertensive subjects



: Kaikkonen JE, Vilppo T, Asikainen J, Voutilainen S, Kurl S, Salonen JT

Publisher: INFORMA HEALTHCARE

: 2013

: Annals of Medicine

: ANNALS OF MEDICINE

: ANN MED

: 5-6

: 45

: 5-6

: 455

: 464

: 10

: 0785-3890

DOI: https://doi.org/10.3109/07853890.2013.809915(external)


Conclusions. We propose that elevated lipid peroxidation is associated with several risk factors of CVD, such as a low PUFA/SFA ratio, whereas the FA precursors of lipid peroxidation, i.e. omega-3 and omega-6 PUFAs are associated with attenuated F-2-IsoP levels. These findings provide mechanistic support for earlier observations linking PUFA to improved cardiovascular health.



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