A1 Refereed original research article in a scientific journal
Fatty acids as determinants of in-vivo lipid peroxidation: The EFFGE study in Eastern Finnish hypertensive and non-hypertensive subjects
Authors: Kaikkonen JE, Vilppo T, Asikainen J, Voutilainen S, Kurl S, Salonen JT
Publisher: INFORMA HEALTHCARE
Publication year: 2013
Journal: Annals of Medicine
Journal name in source: ANNALS OF MEDICINE
Journal acronym: ANN MED
Number in series: 5-6
Volume: 45
Issue: 5-6
First page : 455
Last page: 464
Number of pages: 10
ISSN: 0785-3890
DOI: https://doi.org/10.3109/07853890.2013.809915
Abstract
Conclusions. We propose that elevated lipid peroxidation is associated with several risk factors of CVD, such as a low PUFA/SFA ratio, whereas the FA precursors of lipid peroxidation, i.e. omega-3 and omega-6 PUFAs are associated with attenuated F-2-IsoP levels. These findings provide mechanistic support for earlier observations linking PUFA to improved cardiovascular health.
Conclusions. We propose that elevated lipid peroxidation is associated with several risk factors of CVD, such as a low PUFA/SFA ratio, whereas the FA precursors of lipid peroxidation, i.e. omega-3 and omega-6 PUFAs are associated with attenuated F-2-IsoP levels. These findings provide mechanistic support for earlier observations linking PUFA to improved cardiovascular health.
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