A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Fatty acids as determinants of in-vivo lipid peroxidation: The EFFGE study in Eastern Finnish hypertensive and non-hypertensive subjects
Julkaisun tekijät: Kaikkonen JE, Vilppo T, Asikainen J, Voutilainen S, Kurl S, Salonen JT
Kustantaja: INFORMA HEALTHCARE
Julkaisuvuosi: 2013
Journal: Annals of Medicine
Tietokannassa oleva lehden nimi: ANNALS OF MEDICINE
Lehden akronyymi: ANN MED
Numero sarjassa: 5-6
Volyymi: 45
Julkaisunumero: 5-6
Sivujen määrä: 10
ISSN: 0785-3890
DOI: http://dx.doi.org/10.3109/07853890.2013.809915
Tiivistelmä
Conclusions. We propose that elevated lipid peroxidation is associated with several risk factors of CVD, such as a low PUFA/SFA ratio, whereas the FA precursors of lipid peroxidation, i.e. omega-3 and omega-6 PUFAs are associated with attenuated F-2-IsoP levels. These findings provide mechanistic support for earlier observations linking PUFA to improved cardiovascular health.
Conclusions. We propose that elevated lipid peroxidation is associated with several risk factors of CVD, such as a low PUFA/SFA ratio, whereas the FA precursors of lipid peroxidation, i.e. omega-3 and omega-6 PUFAs are associated with attenuated F-2-IsoP levels. These findings provide mechanistic support for earlier observations linking PUFA to improved cardiovascular health.
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