Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood



: Kucuksezer UC, Palomares O, Ruckert B, Jartti T, Puhakka T, Nandy A, Gemicioglu B, Fahrner HB, Jung A, Deniz G, Akdis CA, Akdis M

Publisher: MOSBY-ELSEVIER

: 2013

: Journal of Allergy and Clinical Immunology

: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

: J ALLERGY CLIN IMMUN

: 3

: 131

: 3

: 875

: 885

: 11

: 0091-6749

DOI: https://doi.org/10.1016/j.jaci.2012.10.051


Conclusion: Certain innate immune response signals and proinflammatory cytokines break allergen-specific CD4(+) T-cell tolerance in normally unresponsive subjects, which might lead to the development or exacerbation of allergic diseases after encountering microbes or inflammatory conditions. (J Allergy Clin Immunol 2013;131:875-85.)



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