A1 Refereed original research article in a scientific journal

Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood



Authors: Kucuksezer UC, Palomares O, Ruckert B, Jartti T, Puhakka T, Nandy A, Gemicioglu B, Fahrner HB, Jung A, Deniz G, Akdis CA, Akdis M

Publisher: MOSBY-ELSEVIER

Publication year: 2013

Journal: Journal of Allergy and Clinical Immunology

Journal name in source: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Journal acronym: J ALLERGY CLIN IMMUN

Number in series: 3

Volume: 131

Issue: 3

First page : 875

Last page: 885

Number of pages: 11

ISSN: 0091-6749

DOI: https://doi.org/10.1016/j.jaci.2012.10.051


Abstract
Conclusion: Certain innate immune response signals and proinflammatory cytokines break allergen-specific CD4(+) T-cell tolerance in normally unresponsive subjects, which might lead to the development or exacerbation of allergic diseases after encountering microbes or inflammatory conditions. (J Allergy Clin Immunol 2013;131:875-85.)



Last updated on 2024-26-11 at 15:43