Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk

: Parikka V, Nanto-Salonen K, Saarinen M, Simell T, Ilonen J, Hyoty H, Veijola R, Knip M, Simell O

Publisher: SPRINGER

: 2012

: Diabetologia

: DIABETOLOGIA

: 7

: 55

: 7

: 1926

: 1936

: 11

: 0012-186X

DOI: https://doi.org/10.1007/s00125-012-2523-3

Conclusions/interpretation Early initiation of autoimmunity and rapid increases in autoantibody titres strongly predict progression to overt diabetes before puberty, emphasising the importance of early life events in the development of type 1 diabetes.