Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk - UTU Research Portal

A1 Refereed original research article in a scientific journal

Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk

Authors: Parikka V, Nanto-Salonen K, Saarinen M, Simell T, Ilonen J, Hyoty H, Veijola R, Knip M, Simell O

Publisher: SPRINGER

Publication year: 2012

Journal: Diabetologia

Journal name in source: DIABETOLOGIA

Journal acronym: DIABETOLOGIA

Number in series: 7

Volume: 55

Issue: 7

First page : 1926

Last page: 1936

Number of pages: 11

ISSN: 0012-186X

DOI: https://doi.org/10.1007/s00125-012-2523-3

Abstract

Conclusions/interpretation Early initiation of autoimmunity and rapid increases in autoantibody titres strongly predict progression to overt diabetes before puberty, emphasising the importance of early life events in the development of type 1 diabetes.