A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study
Tekijät: Jokiranta Elina, Sourander Andre, Suominen Auli, Timonen-Soivio Laura, Alan S. Brown, Matti Sillanpää
Julkaisuvuosi: 2014
Journal: Journal of Autism and Developmental Disorders
Vuosikerta: 44
Numero: 10
Aloitussivu: 2547
Lopetussivu: 2557
Sivujen määrä: 11
ISSN: 0162-3257
DOI: https://doi.org/10.1007/s10803-014-2126-6
Tiivistelmä
The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger's syndrome or pervasive developmental disorders-not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy's age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability.
The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger's syndrome or pervasive developmental disorders-not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy's age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability.
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