A1 Refereed original research article in a scientific journal
Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study
Authors: Jokiranta Elina, Sourander Andre, Suominen Auli, Timonen-Soivio Laura, Alan S. Brown, Matti Sillanpää
Publication year: 2014
Journal: Journal of Autism and Developmental Disorders
Volume: 44
Issue: 10
First page : 2547
Last page: 2557
Number of pages: 11
ISSN: 0162-3257
DOI: https://doi.org/10.1007/s10803-014-2126-6
Abstract
The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger's syndrome or pervasive developmental disorders-not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy's age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability.
The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger's syndrome or pervasive developmental disorders-not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy's age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability.
UTU Research Portal