A2 Refereed review article in a scientific journal
Immune persistence after pertussis vaccination
Authors: Chen Zhiyun, He Qiushui
Publisher: TAYLOR & FRANCIS INC
Publishing place: London
Publication year: 2017
Journal: Human Vaccines and Immunotherapeutics
Journal name in source: HUMAN VACCINES & IMMUNOTHERAPEUTICS
Journal acronym: HUM VACC IMMUNOTHER
Volume: 13
Issue: 4
First page : 744
Last page: 756
Number of pages: 13
ISSN: 2164-5515
eISSN: 2164-554X
DOI: https://doi.org/10.1080/21645515.2016.1259780
Web address : http://www.tandfonline.com/doi/full/10.1080/21645515.2016.1259780?scroll=top≠edAccess=true
Abstract
Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs due to variation in vaccine content, schedule and coverage. Protection following acellular pertussis vaccines has been suggested to wane faster than whole cell pertussis vaccines. However, long-term immune persistence of whole cell pertussis vaccines may be confounded by a progressive acquisition of natural immunity. The World Health Organization has recommended that a switch from whole cell to acellular pertussis vaccines for primary immunization in infants should only be considered if additional periodic boosters or maternal immunization can be ensured and sustained in the national immunization schedules. In this review, we present data on immune persistence after different pertussis vaccinations and compare the findings from countries with different vaccination strategies. Future aspects in serological studies are briefly discussed.
Pertussis is one of the most prevalent vaccine-preventable diseases worldwide. The true infection rate is significantly higher than the reported incidence rate. An increased prevalence of pertussis in older populations has been found, mainly caused by waning immunity after vaccination. Vaccine-induced immunity differs due to variation in vaccine content, schedule and coverage. Protection following acellular pertussis vaccines has been suggested to wane faster than whole cell pertussis vaccines. However, long-term immune persistence of whole cell pertussis vaccines may be confounded by a progressive acquisition of natural immunity. The World Health Organization has recommended that a switch from whole cell to acellular pertussis vaccines for primary immunization in infants should only be considered if additional periodic boosters or maternal immunization can be ensured and sustained in the national immunization schedules. In this review, we present data on immune persistence after different pertussis vaccinations and compare the findings from countries with different vaccination strategies. Future aspects in serological studies are briefly discussed.
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