High-Dose Chemotherapy with Stem Cell Rescue in the Primary Treatment of Metastatic and Pelvic Osteosarcoma: Final Results of the ISG/SSG II Study - UTU Tutkimustietojärjestelmä

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High-Dose Chemotherapy with Stem Cell Rescue in the Primary Treatment of Metastatic and Pelvic Osteosarcoma: Final Results of the ISG/SSG II Study

Tekijät: Boye K, Del Prever AB, Eriksson M, Saeter G, Tienghi A, Lindholm P, Fagioli F, Skjeldal S, Ferrari S, Hall KS

Kustantaja: WILEY-BLACKWELL

Julkaisuvuosi: 2014

Journal: Pediatric Blood and Cancer

Tietokannassa oleva lehden nimi: PEDIATRIC BLOOD & CANCER

Lehden akronyymi: PEDIATR BLOOD CANCER

Vuosikerta: 61

Numero: 5

Aloitussivu: 840

Lopetussivu: 845

Sivujen määrä: 6

ISSN: 1545-5009

DOI: https://doi.org/10.1002/pbc.24868

Tiivistelmä

ConclusionsThe administration of high-dose chemotherapy with stem cell rescue was feasible, but associated with significant toxicity. Patient outcome seemed comparable to previous studies using conventional chemotherapy. We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma. Pediatr Blood Cancer 2014;61:840-845. (c) 2013 Wiley Periodicals, Inc.