High-Dose Chemotherapy with Stem Cell Rescue in the Primary Treatment of Metastatic and Pelvic Osteosarcoma: Final Results of the ISG/SSG II Study - UTU Research Portal

A1 Refereed original research article in a scientific journal

High-Dose Chemotherapy with Stem Cell Rescue in the Primary Treatment of Metastatic and Pelvic Osteosarcoma: Final Results of the ISG/SSG II Study

Authors: Boye K, Del Prever AB, Eriksson M, Saeter G, Tienghi A, Lindholm P, Fagioli F, Skjeldal S, Ferrari S, Hall KS

Publisher: WILEY-BLACKWELL

Publication year: 2014

Journal: Pediatric Blood and Cancer

Journal name in source: PEDIATRIC BLOOD & CANCER

Journal acronym: PEDIATR BLOOD CANCER

Volume: 61

Issue: 5

First page : 840

Last page: 845

Number of pages: 6

ISSN: 1545-5009

DOI: https://doi.org/10.1002/pbc.24868

Abstract

ConclusionsThe administration of high-dose chemotherapy with stem cell rescue was feasible, but associated with significant toxicity. Patient outcome seemed comparable to previous studies using conventional chemotherapy. We conclude that HDCT with carboplatin and etoposide should not be further explored as a treatment strategy in high-risk osteosarcoma. Pediatr Blood Cancer 2014;61:840-845. (c) 2013 Wiley Periodicals, Inc.