Temperament trait Harm Avoidance associates with mu-opioid receptor availability in frontal cortex: A PET study using [C-11]carfentanil

: Tuominen L, Salo J, Hirvonen J, Nagren K, Laine P, Melartin T, Isometsa E, Viikari J, Raitakari O, Keltikangas-Jarvinen L, Hietala J

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

: 2012

: NeuroImage

: NEUROIMAGE

: 3

: 61

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: 1053-8119

DOI: https://doi.org/10.1016/j.neuroimage.2012.03.063(external)

In conclusion, higher Harm Avoidance score in healthy subjects is associated with higher p-opioid availability in regions involved in the regulation of anxiety as well as in the control of emotions, affective component of pain and interoceptive awareness. The results have relevance in the research of vulnerability factors for affective disorders. (c) 2012 Elsevier Inc. All rights reserved.