A1 Refereed original research article in a scientific journal

Temperament trait Harm Avoidance associates with mu-opioid receptor availability in frontal cortex: A PET study using [C-11]carfentanil




AuthorsTuominen L, Salo J, Hirvonen J, Nagren K, Laine P, Melartin T, Isometsa E, Viikari J, Raitakari O, Keltikangas-Jarvinen L, Hietala J

PublisherACADEMIC PRESS INC ELSEVIER SCIENCE

Publication year2012

JournalNeuroImage

Journal name in sourceNEUROIMAGE

Journal acronymNEUROIMAGE

Number in series3

Volume61

Issue3

First page 670

Last page676

Number of pages7

ISSN1053-8119

DOIhttps://doi.org/10.1016/j.neuroimage.2012.03.063(external)


Abstract
In conclusion, higher Harm Avoidance score in healthy subjects is associated with higher p-opioid availability in regions involved in the regulation of anxiety as well as in the control of emotions, affective component of pain and interoceptive awareness. The results have relevance in the research of vulnerability factors for affective disorders. (c) 2012 Elsevier Inc. All rights reserved.



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