Increased Medial Orbitofrontal (18F)fluorodopa Uptake in Parkinsonian Impulse Control Disorders
: Juho Joutsa, Kirsti Martikainen, Solja Niemelä, Jarkko Johansson, Sarita Forsback, Juha O Rinne, Valtteri Kaasinen
: 2012
: Movement Disorders
: 6
: 27
: 6
: 778
: 82
: -695
: 0885-3185
DOI: https://doi.org/10.1002/mds.24941
Background:
Impulse control disorders (ICDs) occur frequently in PD patients.
Methods:To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [18F]fluorodopa PET.
Results:Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [18F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders.
Conclusions:Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine‐replacement therapy in PD. © 2012 Movement Disorder Society
