A1 Refereed original research article in a scientific journal

Increased Medial Orbitofrontal (18F)fluorodopa Uptake in Parkinsonian Impulse Control Disorders



Authors: Juho Joutsa, Kirsti Martikainen, Solja Niemelä, Jarkko Johansson, Sarita Forsback, Juha O Rinne, Valtteri Kaasinen

Publication year: 2012

Journal: Movement Disorders

Number in series: 6

Volume: 27

Issue: 6

First page : 778

Last page: 82

Number of pages: -695

ISSN: 0885-3185

DOI: https://doi.org/10.1002/mds.24941(external)


Abstract
Background:

Impulse control disorders (ICDs) occur frequently in PD patients.

Methods:

To investigate the possible involvement of the mesostriatal and mesolimbic monoaminergic function in ICDs associated with PD, we examined patients with (n = 10) and without (n = 10) ICDs using the brain [18F]fluorodopa PET.

Results:

Patients with ICDs (e.g., pathological gambling, hypersexuality, and compulsive eating) showed up to 35% higher [18F]fluorodopa uptake in the medial orbitofrontal cortex, compared to control patients, but no differences in the striatum. The results remained significant also after excluding subjects with comorbid psychiatric disorders.

Conclusions:

Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine‐replacement therapy in PD. © 2012 Movement Disorder Society



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