Chiral Solid Solutions for the NMR Analysis of Enantiomers: A Potential New Approach to Chiral Analysis

: Karel D Klika

Publisher: HINDAWI PUBLISHING CORPORATION

: NEW YORK; 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA

: 2013

: Journal of spectroscopy

: Journal of Spectroscopy

: J.Spectrosc.

: 970654

: 6

: 2314-4920

DOI: https://doi.org/10.1155/2013/970654

Differences between the solid-state C-13 CP-MAS NMR spectra of holemic samples of the two enantiomers of 2,2'-dihydroxy-1,1'-binaphthyl (binol) were not sufficiently emphatic to reliably distinguish them, though they are readily distinguishable from the spectrum of the bimate of the compound crystallized from an equimatic sample. Inducing an additional chiral environment by cocondensation with sucrose as a chiral selector (CS) provided a method to yield differential spectra for the two enantiomers and thus effect enantiodifferentiation by way of solid-state NMR using weak interactions from a CS.