A1 Refereed original research article in a scientific journal
Chiral Solid Solutions for the NMR Analysis of Enantiomers: A Potential New Approach to Chiral Analysis
Authors: Karel D Klika
Publisher: HINDAWI PUBLISHING CORPORATION
Publishing place: NEW YORK; 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
Publication year: 2013
Journal: Journal of spectroscopy
Journal name in source: Journal of Spectroscopy
Journal acronym: J.Spectrosc.
Article number: 970654
Number of pages: 6
ISSN: 2314-4920
DOI: https://doi.org/10.1155/2013/970654
Abstract
Differences between the solid-state C-13 CP-MAS NMR spectra of holemic samples of the two enantiomers of 2,2'-dihydroxy-1,1'-binaphthyl (binol) were not sufficiently emphatic to reliably distinguish them, though they are readily distinguishable from the spectrum of the bimate of the compound crystallized from an equimatic sample. Inducing an additional chiral environment by cocondensation with sucrose as a chiral selector (CS) provided a method to yield differential spectra for the two enantiomers and thus effect enantiodifferentiation by way of solid-state NMR using weak interactions from a CS.
Differences between the solid-state C-13 CP-MAS NMR spectra of holemic samples of the two enantiomers of 2,2'-dihydroxy-1,1'-binaphthyl (binol) were not sufficiently emphatic to reliably distinguish them, though they are readily distinguishable from the spectrum of the bimate of the compound crystallized from an equimatic sample. Inducing an additional chiral environment by cocondensation with sucrose as a chiral selector (CS) provided a method to yield differential spectra for the two enantiomers and thus effect enantiodifferentiation by way of solid-state NMR using weak interactions from a CS.
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