Evaluation of Ga-68-labeled tracers for PET imaging of myocardial perfusion in pigs

: Tarkia M, Saraste A, Saanijoki T, Oikonen V, Vahasilta T, Strandberg M, Stark C, Tolvanen T, Teras M, Savunen T, Green MA, Knuuti J, Roivainen A

Publisher: ELSEVIER SCIENCE INC

: 2012

: Nuclear Medicine and Biology

: NUCLEAR MEDICINE AND BIOLOGY

: NUCL MED BIOL

: 5

: 39

: 5

: 715

: 723

: 9

: 0969-8051

DOI: https://doi.org/10.1016/j.nucmedbio.2011.11.007

Conclusion: Our results revealed that myocardial accumulation of the Ga-68 chelates proposed for myocardial perfusion imaging with PET was slow and not determined by myocardial perfusion in a large animal model. These findings suggest that the studied tracers are not suitable for clinical imaging of myocardial perfusion. (C) 2012 Elsevier Inc. All rights reserved.