Cholesterol lowering efficacy of plant stanol ester in a new type of product matrix, a chewable dietary supplement



: Laitinen K, Gylling H, Kaipiainen L, Nissinen MJ, Simonen P

Publisher: ELSEVIER SCIENCE BV

: 2017

: Journal of Functional Foods

: JOURNAL OF FUNCTIONAL FOODS

: J FUNCT FOODS

: 30

: 119

: 124

: 6

: 1756-4646

DOI: https://doi.org/10.1016/j.jff.2017.01.012

: https://research.utu.fi/converis/portal/detail/Publication/20524667


Low-density lipoprotein (LDL) cholesterol lowering efficacy of a new type of chewable plant stanol ester food supplement was evaluated in a randomized, double-blind, controlled four-week intervention. The participants (LDL cholesterol > 3 mmol/L) consumed four supplements daily with meals either with (n = 50) or without (n = 53) plant stanol esters. Plant stanol ester supplement (2 g/d plant stanols) lowered LDL cholesterol by 7.6%, serum cholesterol by 4.9%, and non-high density lipoprotein (HDL) cholesterol by 6.6% compared with controls (P < 0.003). HDL cholesterol or serum triacylglycerol concentrations were unchanged. The taste of the supplement was considered good/very good by 68% of the responders, and convenience to consume it was considered easy/very easy by 78% of the responders.No side effects were reported. In conclusion, this new type of small-volume chewable plant stanol ester supplement lowered LDL cholesterol concentration in hypercholesterolemic subjects providing a convenient dietary tool to regulate circulating cholesterol levels. (C) 2017 Elsevier Ltd. All rights reserved.

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