THE Zn2+ COMPLEX OF 1,4,7,10-TETRAAZACYCLODODECANE AS AN ARTIFICIAL NUCLEOBASE

: Laine M, Aromaa M, Virta P, Lönnberg T, Poijärvi-Virta P, Lönnberg H

Publisher: TAYLOR & FRANCIS INC

: 2011

: Nucleosides, Nucleotides and Nucleic Acids

: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

: NUCLEOS NUCLEOT NUCL

: 30

: 7-9

: 609

: 618

: 10

: 1525-7770

DOI: https://doi.org/10.1080/15257770.2011.583809(external)

{2-Deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-alpha-Derythro-pentofuranosyl -N-{2-[4, 7, 10-tris(2,2,2-trifluoroacetyl)-1,4, 7, 10-tetraazacyclododecan-1-yl] ethyl acetamide (I) was prepared and incorporated into a 2'-O-methyl oligoribonucleotide. The hybridization, of this oligonucleotide with complementary 2'-O-methyl oligoribonucleotides incorporating one to five uracil bases opposite to the azacrown structure was studied in the absence and presence of Zn2+ Introduction of Zn2+ moderately stabilized the duplex with U-bulged targets.

Chemical sciences