A1 Refereed original research article in a scientific journal
THE Zn2+ COMPLEX OF 1,4,7,10-TETRAAZACYCLODODECANE AS AN ARTIFICIAL NUCLEOBASE
Authors: Laine M, Aromaa M, Virta P, Lönnberg T, Poijärvi-Virta P, Lönnberg H
Publisher: TAYLOR & FRANCIS INC
Publication year: 2011
Journal: Nucleosides, Nucleotides and Nucleic Acids
Journal name in source: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Journal acronym: NUCLEOS NUCLEOT NUCL
Volume: 30
Issue: 7-9
First page : 609
Last page: 618
Number of pages: 10
ISSN: 1525-7770
DOI: https://doi.org/10.1080/15257770.2011.583809(external)
Abstract
{2-Deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-alpha-Derythro-pentofuranosyl -N-{2-[4, 7, 10-tris(2,2,2-trifluoroacetyl)-1,4, 7, 10-tetraazacyclododecan-1-yl] ethyl acetamide (I) was prepared and incorporated into a 2'-O-methyl oligoribonucleotide. The hybridization, of this oligonucleotide with complementary 2'-O-methyl oligoribonucleotides incorporating one to five uracil bases opposite to the azacrown structure was studied in the absence and presence of Zn2+ Introduction of Zn2+ moderately stabilized the duplex with U-bulged targets.
{2-Deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-alpha-Derythro-pentofuranosyl -N-{2-[4, 7, 10-tris(2,2,2-trifluoroacetyl)-1,4, 7, 10-tetraazacyclododecan-1-yl] ethyl acetamide (I) was prepared and incorporated into a 2'-O-methyl oligoribonucleotide. The hybridization, of this oligonucleotide with complementary 2'-O-methyl oligoribonucleotides incorporating one to five uracil bases opposite to the azacrown structure was studied in the absence and presence of Zn2+ Introduction of Zn2+ moderately stabilized the duplex with U-bulged targets.
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