Electrophilic Addition of Chlorine Monofluoride for PET tracers



: Kirjavainen A, Forsback S, Gronroos TJ, Haavisto L, Haaparanta M, Solin O

Publisher: SPRINGER

: 2013

: Molecular Imaging and Biology

: MOLECULAR IMAGING AND BIOLOGY

: MOL IMAGING BIOL

: 2

: 15

: 2

: 131

: 135

: 5

: 1536-1632

DOI: https://doi.org/10.1007/s11307-012-0584-9


[F-18]ClF is a suitable labeling reagent for electrophilic addition to double bonds of PET tracers. The results show that the modification of the pentafluoro group of [F-18]EF5 by monofluorine-for-chlorine exchange affected the lipophilicity, but the hypoxia avidity of these molecules was not apparently altered.



Last updated on 2024-26-11 at 16:16