A1 Refereed original research article in a scientific journal

Electrophilic Addition of Chlorine Monofluoride for PET tracers



Authors: Kirjavainen A, Forsback S, Gronroos TJ, Haavisto L, Haaparanta M, Solin O

Publisher: SPRINGER

Publication year: 2013

Journal:: Molecular Imaging and Biology

Journal name in source: MOLECULAR IMAGING AND BIOLOGY

Journal acronym: MOL IMAGING BIOL

Number in series: 2

Volume: 15

Issue: 2

First page : 131

Last page: 135

Number of pages: 5

ISSN: 1536-1632

DOI: https://doi.org/10.1007/s11307-012-0584-9


Abstract
[F-18]ClF is a suitable labeling reagent for electrophilic addition to double bonds of PET tracers. The results show that the modification of the pentafluoro group of [F-18]EF5 by monofluorine-for-chlorine exchange affected the lipophilicity, but the hypoxia avidity of these molecules was not apparently altered.



Last updated on 2024-26-11 at 16:16