A1 Refereed original research article in a scientific journal
Electrophilic Addition of Chlorine Monofluoride for PET tracers
Authors: Kirjavainen A, Forsback S, Gronroos TJ, Haavisto L, Haaparanta M, Solin O
Publisher: SPRINGER
Publication year: 2013
Journal: Molecular Imaging and Biology
Journal name in source: MOLECULAR IMAGING AND BIOLOGY
Journal acronym: MOL IMAGING BIOL
Number in series: 2
Volume: 15
Issue: 2
First page : 131
Last page: 135
Number of pages: 5
ISSN: 1536-1632
DOI: https://doi.org/10.1007/s11307-012-0584-9(external)
Abstract
[F-18]ClF is a suitable labeling reagent for electrophilic addition to double bonds of PET tracers. The results show that the modification of the pentafluoro group of [F-18]EF5 by monofluorine-for-chlorine exchange affected the lipophilicity, but the hypoxia avidity of these molecules was not apparently altered.
[F-18]ClF is a suitable labeling reagent for electrophilic addition to double bonds of PET tracers. The results show that the modification of the pentafluoro group of [F-18]EF5 by monofluorine-for-chlorine exchange affected the lipophilicity, but the hypoxia avidity of these molecules was not apparently altered.