A1 Refereed original research article in a scientific journal

Electrophilic Addition of Chlorine Monofluoride for PET tracers




AuthorsKirjavainen A, Forsback S, Gronroos TJ, Haavisto L, Haaparanta M, Solin O

PublisherSPRINGER

Publication year2013

JournalMolecular Imaging and Biology

Journal name in sourceMOLECULAR IMAGING AND BIOLOGY

Journal acronymMOL IMAGING BIOL

Number in series2

Volume15

Issue2

First page 131

Last page135

Number of pages5

ISSN1536-1632

DOIhttps://doi.org/10.1007/s11307-012-0584-9(external)


Abstract
[F-18]ClF is a suitable labeling reagent for electrophilic addition to double bonds of PET tracers. The results show that the modification of the pentafluoro group of [F-18]EF5 by monofluorine-for-chlorine exchange affected the lipophilicity, but the hypoxia avidity of these molecules was not apparently altered.



Last updated on 2024-26-11 at 16:16