[F-18]Fluorination of an arylboronic ester using [F-18]selectfluor bis(triflate): application to 6-[F-18]fluoro-L-DOPA



: Stenhagen ISR, Kirjavainen AK, Forsback SJ, Jorgensen CG, Robins EG, Luthra SK, Solin O, Gouverneur V

Publisher: ROYAL SOC CHEMISTRY

: 2013

: Chemical Communications

: CHEMICAL COMMUNICATIONS

: CHEM COMMUN

: 14

: 49

: 14

: 1386

: 1388

: 3

: 1359-7345

DOI: https://doi.org/10.1039/c2cc38646a


The Ag-mediated electrophilic [F-18]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [F-18]selectfluor bis(triflate) in acetone. The process gave 6-[F-18]-fluoro-L-DOPA with a RCY of 19 +/- 12% and a specific activity of 2.6 +/- 0.3 GBq mu mol(-1).



Last updated on 2024-26-11 at 19:28