A1 Refereed original research article in a scientific journal

[F-18]Fluorination of an arylboronic ester using [F-18]selectfluor bis(triflate): application to 6-[F-18]fluoro-L-DOPA



Authors: Stenhagen ISR, Kirjavainen AK, Forsback SJ, Jorgensen CG, Robins EG, Luthra SK, Solin O, Gouverneur V

Publisher: ROYAL SOC CHEMISTRY

Publication year: 2013

Journal: Chemical Communications

Journal name in source: CHEMICAL COMMUNICATIONS

Journal acronym: CHEM COMMUN

Number in series: 14

Volume: 49

Issue: 14

First page : 1386

Last page: 1388

Number of pages: 3

ISSN: 1359-7345

DOI: https://doi.org/10.1039/c2cc38646a


Abstract
The Ag-mediated electrophilic [F-18]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [F-18]selectfluor bis(triflate) in acetone. The process gave 6-[F-18]-fluoro-L-DOPA with a RCY of 19 +/- 12% and a specific activity of 2.6 +/- 0.3 GBq mu mol(-1).



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