Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1



: Amanpreet Kaur, Jukka Westermarck

Publisher: PORTLAND PRESS LTD

: 2016

Biochemical Society Transactions

BIOCHEMICAL SOCIETY TRANSACTIONS

: BIOCHEM SOC T

: 44

: 6

: 1683

: 1693

: 11

: 0300-5127

: 1470-8752

DOI: https://doi.org/10.1042/BST20160161


Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.



Last updated on 2024-26-11 at 13:40