A2 Refereed review article in a scientific journal
Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1
Authors: Amanpreet Kaur, Jukka Westermarck
Publisher: PORTLAND PRESS LTD
Publication year: 2016
Journal: Biochemical Society Transactions
Journal name in source: BIOCHEMICAL SOCIETY TRANSACTIONS
Journal acronym: BIOCHEM SOC T
Volume: 44
Issue: 6
First page : 1683
Last page: 1693
Number of pages: 11
ISSN: 0300-5127
eISSN: 1470-8752
DOI: https://doi.org/10.1042/BST20160161
Abstract
Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.
Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.
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