Moluccensins R-Y, Limonoids from the Seeds of a Mangrove, Xylocarpus moluccensis

: Li J, Li MY, Feng G, Zhang J, Karonen M, Sinkkonen J, Satyanandamurty T, Wu J

Publisher: AMER CHEMICAL SOC

: 2012

: Journal of Natural Products

: JOURNAL OF NATURAL PRODUCTS

: J NAT PROD

: 7

: 75

: 7

: 1277

: 1283

: 7

: 0163-3864

DOI: https://doi.org/10.1021/np300053f

Eight limonoids, named moluccensins R-Y (1, 2, 5-10), and six known compounds, including 6-hydroxymexicanolide (3), were isolated from the seeds of an Indian mangrove, Xylocarpus moluccensis, collected in the estuaries of Andhra Pradesh. The absolute configuration of moluccensin V (7) was confirmed by means of single-crystal X-ray diffraction analysis. The H-1 and C-13 NMR data for 6-hydroxymexicanolide (3) was assigned for the first time, and the 6R absolute configuration established by single-crystal X-ray diffraction analysis. Moluccensin R (1), 6R-hydroxymexicanolicie (3), and 2-hydroxyfissinolide (4) exhibited marked antifeedant activity against the third-instar larvae of Brontispa longissima at a concentration of 1 mg/mL. The most potent compound tested was 2-hydroxyfissinolide (4), with an AFC(50) (concentration for 50% antifeedant activity) value of 94 mu g/mL at 24 h.