In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor



: Rappu P, Pullinen T, Mantsala P

Publisher: AMER SOC MICROBIOLOGY

: 2003

Journal of Bacteriology

JOURNAL OF BACTERIOLOGY

: J BACTERIOL

: 185

: 22

: 6728

: 6731

: 4

: 0021-9193

DOI: https://doi.org/10.1128/JB.185.22.6728-6731.2003


The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.



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