A1 Refereed original research article in a scientific journal

In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor



Authors: Rappu P, Pullinen T, Mantsala P

Publisher: AMER SOC MICROBIOLOGY

Publication year: 2003

Journal:: Journal of Bacteriology

Journal name in source: JOURNAL OF BACTERIOLOGY

Journal acronym: J BACTERIOL

Volume: 185

Issue: 22

First page : 6728

Last page: 6731

Number of pages: 4

ISSN: 0021-9193

DOI: https://doi.org/10.1128/JB.185.22.6728-6731.2003


Abstract
The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.



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