Hybrid anthracyclines by a genetically engineered Streptomyces galilaeus mutant



: Kunnari T, Niemi J, Ylihonko K, Mantsala P, Hakala J

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

: 1997

: Bioorganic and Medicinal Chemistry Letters

: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

: BIOORG MED CHEM LETT

: 7

: 6

: 725

: 726

: 2

: 0960-894X

DOI: https://doi.org/10.1016/S0960-894X(97)00092-9


A Streptomyces galilaeus mutant carrying genes transfered from S. purpurascens is reported to produce two hybrid anthracyclines. This study demonstrates the possibility of producing hybrid anthracyclines in a combinatorial way by genetic engineering of anthracycline producing strains. (C) 1997 Elsevier Science Ltd.



Last updated on 2025-13-10 at 12:33