A1 Refereed original research article in a scientific journal

Hybrid anthracyclines by a genetically engineered Streptomyces galilaeus mutant



Authors: Kunnari T, Niemi J, Ylihonko K, Mantsala P, Hakala J

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Publication year: 1997

Journal:: Bioorganic and Medicinal Chemistry Letters

Journal name in source: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Journal acronym: BIOORG MED CHEM LETT

Volume: 7

Issue: 6

First page : 725

Last page: 726

Number of pages: 2

ISSN: 0960-894X

DOI: https://doi.org/10.1016/S0960-894X(97)00092-9


Abstract
A Streptomyces galilaeus mutant carrying genes transfered from S. purpurascens is reported to produce two hybrid anthracyclines. This study demonstrates the possibility of producing hybrid anthracyclines in a combinatorial way by genetic engineering of anthracycline producing strains. (C) 1997 Elsevier Science Ltd.



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