Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients
: Iirola T, Ihmsen H, Laitio R, Kentala E, Aantaa R, Kurvinen J-P, Scheinin M, Schwilden H, Schüttler J, Olkkola K
Publisher: OXFORD UNIV PRESS
: 2012
: British Journal of Anaesthesia
: BRITISH JOURNAL OF ANAESTHESIA
: BRIT J ANAESTH
: 3
: 108
: 3
: 460
: 468
: 9
: 0007-0912
DOI: https://doi.org/10.1093/bja/aer441
The population pharmacokinetics of dexmedetomidine was generally in line with results from previous studies. In elderly patients and in patients with hypoalbuminaemia, the elimination half-life and the context-sensitive half-time of dexmedetomidine were prolonged.