Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients




Iirola T, Ihmsen H, Laitio R, Kentala E, Aantaa R, Kurvinen J-P, Scheinin M, Schwilden H, Schüttler J, Olkkola K

PublisherOXFORD UNIV PRESS

2012

British Journal of Anaesthesia

BRITISH JOURNAL OF ANAESTHESIA

BRIT J ANAESTH

3

108

3

460

468

9

0007-0912

DOIhttps://doi.org/10.1093/bja/aer441



The population pharmacokinetics of dexmedetomidine was generally in line with results from previous studies. In elderly patients and in patients with hypoalbuminaemia, the elimination half-life and the context-sensitive half-time of dexmedetomidine were prolonged.




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