Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients - UTU Research Portal

A1 Refereed original research article in a scientific journal

Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients

Authors: Iirola T, Ihmsen H, Laitio R, Kentala E, Aantaa R, Kurvinen J-P, Scheinin M, Schwilden H, Schüttler J, Olkkola K

Publisher: OXFORD UNIV PRESS

Publication year: 2012

Journal: British Journal of Anaesthesia

Journal name in source: BRITISH JOURNAL OF ANAESTHESIA

Journal acronym: BRIT J ANAESTH

Number in series: 3

Volume: 108

Issue: 3

First page : 460

Last page: 468

Number of pages: 9

ISSN: 0007-0912

DOI: https://doi.org/10.1093/bja/aer441

Abstract

The population pharmacokinetics of dexmedetomidine was generally in line with results from previous studies. In elderly patients and in patients with hypoalbuminaemia, the elimination half-life and the context-sensitive half-time of dexmedetomidine were prolonged.