Prognostic value of tumour blood flow, [F-18]EF5 and [F-18]FDG PET/CT imaging in patients with head and neck cancer treated with radiochemotherapy - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Prognostic value of tumour blood flow, [F-18]EF5 and [F-18]FDG PET/CT imaging in patients with head and neck cancer treated with radiochemotherapy

Tekijät: Komar G, Lehtio K, Seppanen M, Eskola O, Levola H, Lindholm P, Sipila H, Seppala J, Grenman R, Solin O, Minn H

Kustantaja: SPRINGER

Julkaisuvuosi: 2014

Journal: European Journal of Nuclear Medicine and Molecular Imaging

Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Lehden akronyymi: EUR J NUCL MED MOL I

Vuosikerta: 41

Numero: 11

Aloitussivu: 2042

Lopetussivu: 2050

Sivujen määrä: 9

ISSN: 1619-7070

DOI: https://doi.org/10.1007/s00259-014-2818-3

Tiivistelmä

Conclusion Our study in a limited number of patients confirmed the importance of MATV in the prognosis of locally advanced squamous cell carcinoma of the head and neck. It is of interest that high uptake of the hypoxia tracer [F-18]EF5 showed a stronger correlation with a poor clinical outcome than [F-18]FDG uptake. This confirms the importance of hypoxia in treatment outcome and suggests that [F-18]EF5 may act as a surrogate marker of radioresistance.